Artikel Jurnal

Comparison Of Clinical Response Between Combine Chemotherapy 5 Fluorourasil - Platinum Based And Ifosfamid - Taxane - Platinum Based In Recurrent Nasopharyngeal Carcinoma

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Background : Recurrence of Nasopharyngeal Carcinoma (NPC) is the emergence of a
tumor remission after administration of chemoradiation based on symptoms and several
examinations. The combination of chemotherapy in recurrent NPC still gives good results.
The combine of regimens used is still varied and not much study has been done to assess
the clinical response. The objectives of this study was to compare the clinical response
between administration of combination 5 Fluorouracil-Platinum based (5-FU) and
Ifosfamide-taxan-platinum based (IFO) in recurrent NPC.
Methods : This observational study used electronic medical record (ERM) data at the ENT
oncology clinic at Dr. Kariadi General Hospital for the period January 2020–January 2022.
The number of samples that suited to the inclusion and exclusion criteria was 44 subjects
divided into two groups of 22 subjects respectively. The chi-square test was used to assess
differences in alteration of clinical symptoms, tumor mass size, neck lymph node
enlargement, tumours stage reduction, and the effect of confounding factors on
response to therapy in both groups.
Results : The highest number of patients with recurrent NPC were aged ≥45 Years old and
male (75%). WHO type 3 is the most common (95.5%) and ECOG status 1 (95.5%). There
was no significant difference administration of the combination of 5-FU with IFO in
alteration of clinical symptoms (p=0.500), shrink tumor size (p=0.347), reduction of neck
lymph node size (p=0.164), and reduction tumor staging (p=0.347). There was no
relationship from confounding factors to clinical response between the administration of
the two groups.
Conclusion : Administration of 5 Fluorouracil-platinum based combination
chemotherapy did not provide a better clinical response in terms of clinical symptoms,
changes in primary tumor size, neck lymph node size, and decreased tumor stage
compared to the Ifosfamide-taxane-platinum based combination based on recurrent
NPC.
Keywords : recurrent nasopharyngeal carcinoma, 5-flourouracil, ifosfamide, response to
therapy.

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Availability

Detail Information

Series Title

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Call Number

616.9948 Rio c

Publisher

Semarang : Medica Hospitalia., 2023

Collation

-

Language

English

ISBN/ISSN

2685-7898

Classification

616.9948

Content Type

text

Media Type

other

Carrier Type

other (computer)

Edition

-

Subject(s)

Chemotherapy, Adjuvant
Nasopharyngeal Neoplasms
Fluorouracil

Specific Detail Info

6 hlm.

Statement of Responsibility

Rio Sanjaya

Viewer

38

Other Information

Tanggal Pelaksanaan - Dari

2024-12-24

Tanggal Pelaksanaan - Sampai

2024-12-24

Akreditasi

Tidak

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