Artikel Jurnal

Effect of Spirulina on Cochlea Histopathological Changes in Wistar Rats Induced by Kanamicin

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Introduction: Streptomycin and kanamycin are aminoglycosides that are toxic to the cochlea vestibular system, can
causing hearing loss. This antibiotic is used for the treatment of tuberculosis and its ototoxicity occurs in 20% of
tuberculosis patients. Spirulina is a cyanobacterial species that is used as a dietary supplement and contains phycocyanin compounds that function as antioxidants and anti-inflammatory. The aim of this study was to determine the
effect of spirulina on histopathological changes in the cochlea in Wistar rats after kanamycin induction. Methods:
this study is a form of posttest-only controlled group design research with a sample of 24 wistar rats divided into
4 groups, namely negative control group, positive control group, treatment group 1 and treatment group 2. Observations of the study took place in November-December 2021. Histopathological measurements in hair cells, macrophages and cochlear vasculature. The analysis used non-parametric Kruskal-Wallis and post-hoc Mann-Whitney
tests. Results: There were more hair cell damage, macrophage cell count, and significant vascular dilatation in the
kanamycin group than in the without kanamycin group with the value p=0.001. There was significantly less number
of hair cell damage in the kanamycin group with spirulina at a dose of 1000 mg than in the kanamycin group with
spirulina at a dose of 400 mg p=0.045. Conclusion: There was a significant effect on the administration of spirulina
on histopathological changes in the cochlea of rats.
Keywords: Histopathology, Kanamycin, Ototoxicity, Spirulina

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Availability

Detail Information

Series Title

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Call Number

616.28 Pri e

Publisher

Malaysia : Malaysian Journal of Medicine and Health Sciences., 2023

Collation

-

Language

English

ISBN/ISSN

2636-9346

Classification

616.28

Content Type

text

Media Type

computer

Carrier Type

other (computer)

Edition

-

Subject(s)

Spirulina
Cochlea
Rats, Wistar

Specific Detail Info

7 hlm.

Statement of Responsibility

Prima Erlangga Harinto

Viewer

87

Other Information

Tanggal Pelaksanaan - Dari

2024-12-23

Tanggal Pelaksanaan - Sampai

2024-12-23

Akreditasi

Tidak

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