Artikel Jurnal

The Effect of 1% Povidone Iodine Mouthwash on The Incidence of Oral Mucositis and Odynophagia in Patients with Head and Neck Malignancy

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Background : Oral mucositis is an injury of normal mucosal tissue with an acute
inflammation of the oral, tongue, and pharyngeal mucosa after exposure to chemoradiotherapy. Post chemoradiotherapy oral mucositis is commonly accompanied by
painful swallowing or odynophagia. Povidone iodine 1% is an antiseptic mouthwash that
widely used to prevent infections in the oral cavity. The aim of this study was to determine
the effect of 1% povidone iodine mouthwash on the incidence of oral mucositis in
patients with head and neck malignancy at Dr. Kariadi General Hospital Semarang.
Methods : This study was single random blinded experimental study, with total samples
of 44 patients with head and neck malignancy after chemoradiotherapy. The samples
divided into treatment group of 22 samples with 1% povidone iodine mouthwash and
control group of 22 samples with NaCl 0.9% recruited using single random sampling at
Dr. Kariadi Semarang General Central Hospital in 2022. The effect of 1% povidone iodine
mouthwash on the incidence of oral mucositis and odynophagia was analyzed using the
Fischer Exact and Mann Whitney test.
Results : In the 1% povidone iodine mouthwash group day 15th, 21 patients (95.5%) were
found without mucositis and 1 patient (4.5%) with mucositis oral grade I. In the 1%
povidone iodine mouthwash group, 21 people (4.5%) were found without odynophagia
and 1 people (4.5%) had odynophagia. There was an association between oral mucositis
and odynophagia on povidone iodine 1% group (p < 0.05).
Conclusion : Povidone iodine 1% mouthwash can affect the incidence of oral mucositis in
patients with head and neck carcinoma. Povidone iodine 1% mouthwash can reduce the
incidence of oral mucositis and odynophagia compared to placebo in patients with head
and neck carcinoma.
Keywords : oral mucositis, povidone iodine 1%, odynophagia, head and neck malignancy

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Availability

Detail Information

Series Title

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Call Number

616.99424 Pen t

Publisher

Semarang : Medica Hospitalia., 2023

Collation

-

Language

English

ISBN/ISSN

2685-7898

Classification

616.99424

Content Type

text

Media Type

computer

Carrier Type

other (computer)

Edition

-

Subject(s)

Povidone-Iodine
Mouthwashes
Stomatitis

Specific Detail Info

6 hlm.

Statement of Responsibility

Peny Handayani

Viewer

51

Other Information

Tanggal Pelaksanaan - Dari

2024-12-23

Tanggal Pelaksanaan - Sampai

2024-12-23

Akreditasi

Tidak

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