Artikel Jurnal

The Effect of Green Mussel (Perna viridis) Shells’ Hydroxyapatite Application on Alkaline Phosphatase Levels in Rabbit Femur Bone Defect

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Background: A non-union fracture is one of the most common complications arising from an untreated fracture. Bone grafts are able to fasten bone healing which can prevent and cure non-union fractures. Therefore, alternative hydroxyapatite bone grafts from waste resources are needed to increase the availability of bone grafts in the healthcare system. A bone substitute, hydroxyapatite (HA), has the ability to prevent non-union fractures. Green mussel shell contains 95.69 percent HA, allowing for an annual production of 133.97–287.07 tons per ha of HA, and is a potent alternative material in the manufacture of HA.
Methods: This research was conducted for four months using a true experimental research method with a post-test-only control group design. This study used 36 New Zealand rabbits (Oryctolagus cuniculus) which were divided into 9 groups: positive control, negative control, and intervention at weeks 2, 4 and 6 after the intervention. All groups were subjected to three general procedures: pre-surgery, surgery, and post-surgery.
Results: The findings demonstrated that green mussel shell HA has efficacy in accelerating bone healing, better than HA bovine, as compared to the 6-week negative control group and demonstrated a significant difference (p < 0.05).
Conclusions: Green mussel hydroxyapatite is proven to be able to fasten and maximize the bone healing process as fast as bovine HA, and even has higher efficacy than bovine HA.
Keywords
Hydroxyapatite, green mussel shell, bone substitute, bone healing, alkaline phosphatase

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Availability

Detail Information

Series Title

-

Call Number

617.3 Kev t

Publisher

: F1000Research., 2023

Collation

-

Language

English

ISBN/ISSN

2046-1402

Classification

617.3

Content Type

text

Media Type

computer

Carrier Type

other (computer)

Edition

-

Subject(s)

Hydroxyapatites
Alkaline Phosphatase
Femur

Specific Detail Info

18 hlm.

Statement of Responsibility

Kevin Christian Tjandra

Viewer

763

Other Information

Tanggal Pelaksanaan - Dari

2024-12-24

Tanggal Pelaksanaan - Sampai

2024-12-24

Akreditasi

Tidak

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