Artikel Jurnal

Supplementation in suppressing Troponin I and NTproBNP level in breast cancer patients with 5- fluorouracil, adriamycin, andcyclophosphamide chemotherapy

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Background: Breast cancer is a malignancy originating from breast tissue, where chemotherapy is one of the choice therapy.
Doxorubicin, 5-fluorouracil, and cyclophosphamide (FAC) are the most commonly used combination of chemotherapy. One
of the side effects of chemotherapy is cardiotoxicity. Multiflora honey prevents cardiotoxic effects through its flavonoids and
polyphenols compounds. The aim of this research is to analyze the effectiveness of adding honey in preventing cardiotoxic
effects in breast cancer patients receiving FAC chemotherapy.
Methods: An experimental study with double-blind randomized pre and post-test with control group design. Ductal invasive
breast cancer patients were divided into 2 groups, the control group, who received FAC chemotherapy (n=18) and the
treatment group, who received chemotherapy and 90 ml/day honey consumption for 14 days (n=18). The patient’s Troponin
I and NT-proBNP enzyme levels before and after 14 days of the study were assessed.
Results: Post-treatment, there was an increase in Troponin I levels from the treatment group (0.22 ± 0.07 vs. 0.24 ± 0.07)
vs. control (0.25 ± 0.11 vs. 0.34 ± 0.20) with a significant difference. (p = 0.031). There was a decrease in NT-proBNP levels
in the treatment group (461.0 ± 610.4 vs. 215.6 ± 260.3) and an increase in NT-proBNP levels (275.9 ± 392.4 vs. 315.4 ±
293.9) with a significant difference (p = 0.006).
Conclusion: Multiflora honey can prevent cardiotoxic effects in breast cancer patients receiving FAC chemotherapy.

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Detail Information

Series Title

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Call Number

618.19 STE s

Publisher

Bali : Bali Medical Journal., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

618.19

Content Type

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Media Type

-

Carrier Type

-

Edition

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Subject(s)

Breast Neoplasms
Chemotherapy, Adjuvant
Fluorouracil

Specific Detail Info

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Statement of Responsibility

Stefanus Satria Adi Dharma

Viewer

81

Other Information

Tanggal Pelaksanaan - Dari

2024-12-27

Tanggal Pelaksanaan - Sampai

2024-12-27

Akreditasi

Tidak

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