Image of The Effects of Cholecalciferol 1000 IU Supplementation on Handgrip Strength in Elderly with Vitamin D Deficiency

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The Effects of Cholecalciferol 1000 IU Supplementation on Handgrip Strength in Elderly with Vitamin D Deficiency

Backgrounds: Vitamin D regulates muscle function by binding to vitamin D receptors
(VDR) via genomic signaling pathways. The biologically active form of vitamin D (1,25-
(OH)D) affects muscles by modulation of gene transcription and protein kinase
signaling pathways that support proliferation and muscle growth. Aging will result in
the interaction of vitamin D and VDR, affecting the regulation of muscle calcium
channels, followed by a decrease in the stimulation of muscle contractions.
Decreased synthesis and low vitamin D intake also affect serum level 25(OH)D.
Maintaining vitamin D status in the elderly with vitamin D deficiency is expected to
inhibit the decline in muscle strength and dysfunction.
Objectives: Determining the effect of giving cholecalciferol on handgrip strength.
Methods: An experimental study with randomized controlled trial (RCT) enrolled 54
elderly divided into treatment and control groups. The treatment group received
cholecalciferol 1000 IU/day, and the control group received a placebo for 12 weeks.
Both groups were examined for serum 25(OH) levels before and after treatment.
Results: Most samples in both groups (79.62%) showed vitamin D deficiency. There
was an effect of 1000 IU cholecalciferol supplementation on serum 25(OH)D levels
with a mean change of 3.8 (p

Availability
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Perpustakaan RSUP Dr. Kariadi Semarang 612.044 Ika t
P00399S
Available
Detail Information
Series Title
-
Call Number
612.044 Ika t
Publisher
Surabaya : Amerta Nutrition.,
Collation
-
Language
English
ISBN/ISSN
2580-1163
Classification
612.044
Content Type
text
Media Type
other
Carrier Type
other (computer)
Edition
-
Subject(s)
Cholecalciferol
Vitamin D Deficiency
Aged
Specific Detail Info
7 hlm.
Statement of Responsibility
Viewer
28
Other Information
Tanggal Pelaksanaan - Dari
2024-12-27
Tanggal Pelaksanaan - Sampai
2024-12-27
Akreditasi
Tidak
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