Artikel Jurnal

Immunohistochemical Expression of IDH1, ATRX, Ki67, GFAP, and Prognosis in Indonesian Glioma Patients

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Background: The current World Health Organization (WHO) 2021 classification of human glioma is based on key molecular biomarkers
to define neoplastic entities. This review further delineates mutant IDH (isocitrate dehydrogenase) from wild-type IDH disease, a necessity
given the large survival gap between mutant IDH and wild-type IDH tumors. In Indonesia, there are currently few reports on the distribution
and significance of these mutations. Therefore, this research aims to determine the relationship between IDH mutations, as well as
clinicopathological and prognostic factors in patients with gliomas. Other immunohistochemical markers including ATRX (alphathalassemia/mental retardation, X-linked), Ki67 and GFAP (glial fibrillary acidic protein) expression were also evaluated.
Methods: Forty-two glioma samples were collected from patients who underwent surgery at Dr. Kariadi General Hospital in
Semarang, Central Java, Indonesia. Fresh and paraffin-embedded, formalin-fixed tissue samples were removed and sectioned for
hematoxylin and eosin staining, immunohistochemistry, and IDH analysis of mutation. Medical records were used to collect
clinicopathological and survival data.
Results: IDH1 mutations were discovered in 32 (76,1%) patients, and those with IDH1 mutation had longer overall survival when
corresponded to patients with IDH1-wild-type. Lower expression of Ki67 was discovered to be very associated with a better prognosis.
Conclusion: IDH1 mutations status showed a significant relationship with prognosis in patients with glioma. Meanwhile, other
markers (ATRX, Ki67, and GFAP) did not correlate with the prognosis.
Keywords: IDH1, immunohistochemical expression, prognosis, glioma, Indonesia

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Availability

Detail Information

Series Title

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Call Number

616.994810757 Dod i

Publisher

: International Journal of General Medicine., 2023

Collation

-

Language

Indonesia

ISBN/ISSN

1178-7074

Classification

616.994810757

Content Type

text

Media Type

computer

Carrier Type

other (computer)

Edition

-

Subject(s)

Glioma
Immunohistochemistry
Ki-67 Antigen

Specific Detail Info

11 hlm.

Statement of Responsibility

Dody Priambada

Viewer

98

Other Information

Tanggal Pelaksanaan - Dari

2024-12-27

Tanggal Pelaksanaan - Sampai

2024-12-27

Akreditasi

Tidak

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