Artikel Jurnal

Correlation between Interleukin-17 Levels with C-Reactive Protein and Neutrophil Lymphocyte Ratio in Sepsis

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Background:Sepsis is a condition in systemic infection associated with organ dysfunction. Interleukin-17 is a pro-inflammatory cytokine produced by Th-17 cells. C-reactive protein and neutrophil-lymphocyte ratio (NLR) have been widely used as markers of inflammation.The relationship between IL-17 as a proinflammatory cytokine with CRP and NLR has not been reported.Objective: This study aims to prove the correlation between IL-17 with CRP and NLR in septic patients.Methods:Analytical observational study with a cross-sectional approach was carried out on 40 septic patients in July–December 2020. IL-17 levels were obtained by the ELISA method while CRP levels were obtained using the immunoturbidimetric method. NLR was the result of dividing the absolute number of neutrophils and lymphocytes from the automatic hematology analyzer. Correlation between variables was performed using Spearman correlation test.Results:The median levels of IL-17, CPR, and NLR were 363.55 (11.4-1695.80) pg/mL, 13.25 (0.43-53.87) mg/L, and 12.00 (2.26–48.5), respectively. The Spearman correlation test between IL-17 levels and CRP obtained p = 0.019, r = 0.37, and NLR p = 0.425, r = 0.13.Conclusion: There is a weak positive correlation between IL-17 levels and CRP in septic patients. There is no correlation between IL-17 levels and NLR in septic patients.

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Availability

Detail Information

Series Title

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Call Number

616.9 DWI c

Publisher

Semarang : Journal of Biomedicine and Translational Research., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

616.9

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Interleukin-17
Inflammation
Biomarkers

Specific Detail Info

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Statement of Responsibility

Dwi Retnoningrum

Viewer

95

Other Information

Tanggal Pelaksanaan - Dari

2024-12-27

Tanggal Pelaksanaan - Sampai

2024-12-27

Akreditasi

Tidak

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