Artikel Jurnal

The Correlation of Long-Term Combination Treatment of Valproic Acid and Topiramate on Serum Vitamin D Levels Among Children With Epilepsy

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Background: Epilepsy is a chronic condition characterized by unprovoked seizure. Vitamin D is necessary in child development process and is strongly influenced by the presence of anti-epileptic drugs. Objective: To determine the correlation of treatment duration and serum vitamin D levels in children with epilepsy who use the combination of valproic acid and topiramate. Methods: A cross sectional study among forty pediatric patients with epilepsy with age range of 5-10 years at Dr. Kariadi Hospital Semarang. Examination of serum vitamin D levels is done by ELISA. Statistical analysis using Spearman correlation test and partial correlation test with significance level p = 0.05. Results: The mean of serum vitamin D levels in patient with combination treatment after 24 months was 21.87±1.21ng/ml, in those who still having seizure was 27.94±2.40ng/ml, and among who received delayed therapy was 23.23±2.07ng/ml. Bivariate analysis depicted that there was negative correlation between duration of treatment (rho= -0.850, p

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Detail Information

Series Title

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Call Number

616.85 HEX t

Publisher

Semarang : Diponegoro Medical Journal (Jurnal Kedokteran Diponegoro)., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

616.85

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Epilepsy
Valproic Acid
Topiramate

Specific Detail Info

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Statement of Responsibility

Hexanto Muhartomo

Viewer

131

Other Information

Tanggal Pelaksanaan - Dari

2024-12-30

Tanggal Pelaksanaan - Sampai

2024-12-30

Akreditasi

Tidak

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