The Expression of HIF-1α in Diffuse Large B-cell Lymphoma (DLBCL) Patients: A Cross-Sectional Study in Indonesia

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The Expression of HIF-1α in Diffuse Large B-cell Lymphoma (DLBCL) Patients: A Cross-Sectional Study in Indonesia

Eko Adhi Pangarsa, MD - Personal Name; Sofia Mubarika Haryana, MD, PhD - Personal Name; Damai Santosa, MD, PhD - Personal Name; Budi Setiawan, MD, PhD - Personal Name; Antonius Gunawan Santoso, MD, PhD - Personal Name; Dik Puspasari, MD - Personal Name; Hermawan Istiadi, MD - Personal Name; Sigit P. Kurniawan, MD - Personal Name; Ridho M. Naibaho, MD - Personal Name; Kevin Tandarto, MD - Personal Name; Daniel Rizky, MD - Personal Name; Catharina Suharti, MD, PhD - Personal Name;

Introduction: Hypoxia fuels cancer growth by supporting blood vessel formation, suppressing immune response, and helping
cancer cells adapt to harsh surroundings. This happens when cancer cells react to low oxygen levels by activating hypoxia inducible
factor-1 alpha (HIF-1α). High levels of HIF-1α can indicate an aggressive form of cancer and resistance to treatment in diffuse large
B-cell lymphoma (DLBCL) patients. This study aimed to identify which factors are linked to HIF-1α distribution using
immunohistochemistry in DLBCL patients.
Method: This study conducted at a hospital in Indonesia between 2020 and 2022 aimed to investigate factors associated with HIF1α expression in DLBCL patients. Newly diagnosed DLBCL patients were categorized into two groups based on HIF-1α distribution
(< 40% and ≥40%). Various factors were analyzed between the two groups using statistical tests such as χ2, Mann–Whitney U, and
Spearman correlation tests.
Results: In this study, 40 participants diagnosed with DLBCL were divided into two groups based on their HIF-1α distribution. The
group with HIF-1α distribution greater than or equal to 40% had a higher incidence of extranodal involvement, including primary
extranodal disease, compared to the group with less than 40% distribution. This difference was statistically significant. The authors
also found that haemoglobin level statistically significant (P= 0.041) in this research. The Spearman test analysis showed negative
correlation between haemoglobin (P =

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Perpustakaan RSUP Dr. Kariadi Semarang 616.99483 Eko t

P00418S

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Detail Information

Series Title: -
Call Number: 616.99483 Eko t
Publisher: : Annals of Medicine and Surgery., 2023
Collation: -
Language: English
ISBN/ISSN: -
Classification: 616.99483
Content Type: text
Media Type: computer
Carrier Type: other (computer)
Edition: -
Subject(s): Lymphoma, Large B-Cell, Diffuse
Lymphoma, B-Cell
Gene Expression Regulation, Neoplastic
Specific Detail Info: 8 hlm.
Statement of Responsibility: Eko Adhi Pangarsa, MD
Viewer: 565

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Tanggal Pelaksanaan - Dari: 2024-12-30
Tanggal Pelaksanaan - Sampai: 2024-12-30
Akreditasi: Tidak

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The expression of hypoxia inducible factor-1 alpha in diffuse large B-cell lymphoma (DLBCL) patients: a cross-sectional study in Indonesia

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