Artikel Jurnal

Apolipoprotein E Polymorphism and Carotid Intima Medial Thickness Progression in Post Ischemic Stroke Patient

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Background : Apolipoprotein E (APOE) gene is believed to associate with cholesterol
level, a risk factor of ischemic stroke. CIMT (carotid intima-media thickness) can be used
to determine the degree of atherosclerosis. Increased CIMT may predict ischemic stroke
recurrence. This study aimed to determine association between increased CIMT in post
ischemic stroke patients and APOE genotype.
Methods : This was an epidemiological prospective study involving 71 post ischemic
stroke patients (1 month from onset), admitted from 2012 to 2013. CIMT was examined
with st th nd carotid duplex ultrasound at 1 , 6 , and 12 month after stroke onset. APOE gene
polymorphism was examined using HRM (high-resolution melting) which is a simple
method, accurate, and sensitivefor genotyping.
Results : We found 5 APOE gene variation categories, i.e. E2E3, E2E4, E3E3, E3E4, and
E4E4. The most common allele was E3 and genotype groups E3E3 was the majority of the
population. E2E4 allele had st th the highest CIMT level among others, in the 1 month, 6
month, and 12nd month after stroke, with no association with hypertension, diabetes,
and hypercholesterolemia. E3E3 allele was most often associated with hypertension,
diabetes mellitus, dyslipidemia, and hyperhomocysteinemia.
Conclusion : The results showed that APOE genotype E2E4 may independently constitute
risk factor for atherosclerosis progression (CIMT) in post ischemic stroke patients. While
the E3E3 genotype was often associated with hypertension, diabetes mellitus,
dyslipidemia, and hyperhomocysteinemia. Our results suggest that APOE E4 was not an
important risk factor for carotid atherosclerosis in post ischemic stroke patient.
Keywords : APOE, atherosclerosis, CIMT, post ischemic stroke

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Availability

Detail Information

Series Title

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Call Number

616.83 ADI a

Publisher

Semarang : Medica Hospitalia., 2022

Collation

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Language

English

ISBN/ISSN

-

Classification

616.83

Content Type

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Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Stroke
Carotid Arteries
Carotid Intima-Media Thickness

Specific Detail Info

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Statement of Responsibility

Aditya Kurnianto

Viewer

245

Other Information

Tanggal Pelaksanaan - Dari

2024-12-31

Tanggal Pelaksanaan - Sampai

2024-12-31

Akreditasi

Tidak

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