Artikel Jurnal

Profile of Cachexia Parameters and Dietary Intakes in Advanced Stage of Nasopharyngeal Cancer Patients: Study inThree Hospitals in Semarang, Central Java, Indonesia

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Background: Nasopharyngeal cancer (NPC) patients have high risk of cachexia. It is important to notice
cachexia parameters in the beginning of their treatment in order to predict and anticipate unexpected
outcomes. This study aimed to describe the profile of advanced stage NPC patient receiving first
chemotherapy, especially in cachexia parameters and dietary intakes. Methods: A cross-sectional study
was conducted involving advanced stage of NPC patients who would receive their first chemotherapy
aged 20-70 years. Subjects with distant metastatic, acute infection, history of past chemotherapy or
radiotherapy, were excluded. Parameters of cachexia being studied were inflammation markers (NLR and
CRP level), anorexia and fatigue scores, body composition (fat and muscle mass) and hand grip strength
(HGS), meanwhile dietary intakes were energy and protein. Frequency distribution, descriptive statistic,
and Pearson correlation test were used in data analyses. Results: Forty-three subjects were participated.
Average age was48.1±9.8 years old and 63% were males. NLR and CRP level were high, i.e.4.8±5.0 and
13.3±20.6 mg/dL, respectively. Anorexia and fatigue scores were 32.4±9 and 35.9±11.8, respectively,
with 70% subjects were anorexic and 30% subjects experienced severe fatigue. Less than 20% were
malnourished but 35% subjects had central obesity and 37% subjects classified to have very high fat
mass. Most subjects had low muscle mass (77%) and classified to have weak HGS (77%). Energy and
protein intakes were 26.7±8.9 kcal/kgBW/d and 1±0.4 g/kg BW/d respectively. Some variables had strong
correlation (r≥0.80), i.e. BMI with visceral fat (r=0.94), fat with muscle mass (r=-0.89), energy with
protein intakes (r=0.80), and moderate correlation (r=0.60–0.79) between anorexia and fatigue scores.
Conclusions: Advanced stage of NPC patients receiving first chemotherapy had high inflammation
status, anorexia and fatigue. Many subjects had low muscle mass and weak HGS. BMI with visceral fat,
fat with muscle mass, energy with protein intake, were strongly correlated.
Keywords: cachexia; nasopharyngeal cancer; chemotherapy; dietary intake; Indonesia.

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Availability

Detail Information

Series Title

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Call Number

616.994 MIN p

Publisher

Bangladesh : Bangladesh Journal of Medical Science., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

616.994

Content Type

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Media Type

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Carrier Type

-

Edition

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Subject(s)

Nasopharyngeal Neoplasms
Cachexia
Malnutrition

Specific Detail Info

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Statement of Responsibility

Minidian Fasitasari

Viewer

120

Other Information

Tanggal Pelaksanaan - Dari

2024-12-31

Tanggal Pelaksanaan - Sampai

2024-12-31

Akreditasi

Tidak

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