Artikel Jurnal

The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients

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Abstract: Nasopharyngeal carcinoma (NPC) is a malignant
tumor that grows from the epithelial cells of nasopharynx.
NPC has the ability to modify its metabolism and leads
the patient to suffer from malnutrition and cachexia,
therefore aggravates the occurrence of impaired inflammatory response. Currently, available treatments for NPC
are chemotherapy, radiotherapy, or chemoradiotherapy.
Despite of its efficacy, these regimens have been known to
elicit various inflammation-related side effects including
infection, diarrhea, and mucositis. It has long been established that increased activity of inflammatory response is
associated to low survival rate in both early and advanced
stage of cancer. Furthermore, uncontrolled and dysregulated inflammatory response are significantly correlated
with malignant progression of cancer. Considering how
pivotal inflammation to malignancy progression, there is a
need for effective strategies to modulate inflammatory
response. Various strategies have been proposed to
improve immune response in NPC patients including dietary supplementation of synbiotics. Synbiotics refers to
the manipulation of both probiotics and prebiotics to provide a synergistic benefit to the host by promoting the
growth of beneficial bacteria while inhibiting the growth of
pathogenic bacteria. There is a growing number of evidences related to the potential of synbiotics in modulating
the pro-inflammatory response and improve immune systems in a variety of conditions, including cancer. In this
study, we will discuss the immunomodulatory effects of
synbiotics in the nasopharyngeal carcinoma occurrences.
Keywords: nasopharyngeal carcinoma; nutrition; oncology;
prebiotics; probiotics; synbiotics

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Availability

Detail Information

Series Title

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Call Number

616.99 MIN t

Publisher

Jerman : Journal of Basic and Clinical Physiology and Pharmacology., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

616.99

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Nasopharyngeal Neoplasms
Synbiotics
Inflammation

Specific Detail Info

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Statement of Responsibility

Minidian Fasitasari

Viewer

105

Other Information

Tanggal Pelaksanaan - Dari

2025-01-01

Tanggal Pelaksanaan - Sampai

2025-01-01

Akreditasi

Tidak

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