Artikel Jurnal

Effect of Channa striata Extract Supplementation on Febrile Neutropenia in Acute Myeloid Leukemia Patients Undergoing Chemotherapy: A Randomized Controlled Study 2024

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Introduction: Febrile neutropenia is one of the most serious complications in patients with hematological
malignancies and chemotherapy. Channa striata is a freshwater fish belonging to the family Channidae. This study aims
to determine whether the administration of channa striata extract can increase neutrophil count, neutrophil function
and prevent incidence of febrile neutropenia in acute myeloid leukemia (AML) patients receiving chemotherapy.
Method: A randomized, single-blind, controlled study compared a standard nutrition from hospital with a channa striata
extract–supplemented per oral containing 6 grams of channa striata extract in patients with acute myeloid leukemia
undergoing intensive chemotherapy. To analyze the effects of channa striata extract on function of neutrophil, Interleukin
(IL)-6 and nitric oxide (NO) levels which are the result of neutrophil phagocytosis were assessed. Results: A total of
32 AML patients were randomized to receive per oral supplementation of channa striata extract (6 g/day) or nutrition
from the hospital during intensive chemotherapy and after chemotherapy. The median onset of neutropenia was 6.1
+ 3.37 in the channa striata extract group and 8.8 + 4.59 in the control group (p=0.109). The median duration of
neutropenia was 12.8 + 6.20 d in the channa striata group and 17.2 + 11.06 d in the control group (p=0.281), whereas
the incidence of febrile neutropenia were 85,7% in the channa striata extract group and 43,8% in the control group
with median duration of neutropenic fever were 5.7 + 3.56 and 4.7 + 4.57, respectively. The chi-square test in the IL-6
delta category showed a tendency for IL-6 levels to rise in 61.5% of subjects in the Channa striata group compared to
the control group (p=0.182). Conclusion: Channa striata extract supplementation did not influence neutropenia onset,
duration, neutrophil function, or neutropenic fever in AML patients.
Keywords: Channa striata extract- AML- intensive chemotherapy- febrile neutropenia

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Availability

Detail Information

Series Title

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Call Number

616.99 BUD e

Publisher

Iran : Asian Pacific Journal of Cancer Prevention., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

616.99

Content Type

-

Media Type

-

Carrier Type

-

Edition

TAHUN 2024

Subject(s)

Leukemia
Neutropenia
Antineoplastic Agents

Specific Detail Info

https://doi.org/10.31557/APJCP.2024.25.12.4265

Statement of Responsibility

Budi Setiawan

Viewer

21

Other Information

Tanggal Pelaksanaan - Dari

2024-12-15

Tanggal Pelaksanaan - Sampai

2024-12-15

Akreditasi

Tidak

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