Artikel Jurnal

Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study 2025

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Background: Multiple myeloma (MM) is characterized by reduced circulating
adiponectin levels, a condition associated with various diseases such as diabetes
mellitus, obesity, cardiovascular diseases, cancer, and plasma dyscrasias. Curcumin has
been shown to inhibit adipogenesis and elevate serum adiponectin levels. Notably,
limited studies investigating the relationship between adiponectin levels and curcumin
supplementation in myeloma patients. This study is to evaluate the efficacy curcumin
supplements on increasing the levels of adiponectin in myeloma patients
Methods: Patients with myeloma were randomly to melphalan, prednisone, curcumin
(MPC) (n=17) and melphalan with prednisone (MP) (n=16) groups. The MPC group
was treated by melphalan 4 mg/m2
and prednisone 40 mg/m2
for 7 days (MP), and
curcumin 8 grams daily for 28 days. The MP group received MP and placebo. Subjects
were followed-up every 28 days and a total of four treatment cycles. Hemoglobin,
albumin, white blood cell (WBC), platelets, urea, creatinine, calcium, protein M, and
adiponectin evaluated before and after treatment. Mann Whitney test or the Independent
T-test were used to analysis
Results: Total subject (24 subjects) completed the treatment. Serum adiponectin levels
after four treatment cycles in the MPC group were higher than in the MP group [(mean,
12227.15748.3) vs (11365.49175.5), P = 0.78]
Conclusion: Supplementing MP regimen with 8000 mg curcumin daily for 28 days
increases the serum adiponectin level after four treatment cycles in myeloma patients.
This research found that myeloma patients may benefit by taking curcumin
supplementation.
Keywords: Multiple myeloma, Curcumin, Adiponectin.

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Availability

Detail Information

Series Title

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Call Number

616.99 DAM a

Publisher

Iran : Caspian Journal of Internal Medicine., 2025

Collation

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Language

English

ISBN/ISSN

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Classification

616.99

Content Type

-

Media Type

-

Carrier Type

-

Edition

TAHUN 2025

Subject(s)

Multiple Myeloma
Adiponectin
Curcumin

Specific Detail Info

https://doi.org/10.22088/cjim.16.2.320

Statement of Responsibility

Damai Santosa

Viewer

11

Other Information

Tanggal Pelaksanaan - Dari

2025-03-21

Tanggal Pelaksanaan - Sampai

2025-03-21

Akreditasi

Tidak

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