Background: Spinocerebellar ataxia (SCA) is a late onset neurodegenerative disorder in which coordination and balance are affected. Although many international guidelines have been established regarding presymptomatic testing, it is still a grey area in Indonesia. We report two large families with advanced stages of SCA who underwent presymptomatic gene…
Latar belakang : Obstructive Sleep Apnea (OSA) ditandai dengan adanya obstruksi jalan napas yang menyebabkan napas berhenti sesaat, baik secara total maupun parsial. OSA dapat menyebabkan komplikasi yang berat. Diagnostik pasti OSA dengan polisomnografi (PSG). PSG tidak banyak tersedia di fasilitas kesehatan, pemeriksaan friedman tongue position (FTP) diharapkan dapat menjadi pemeriksaan se…
Background:Leprosy is a chronic infectious peripheral neuropathy caused by Mycobacterium leprae. Clinical presentations of leprosy neuropathy are obtained when the nerve damage is more than 30% of peripheral nerve fibers. The anti-inflammatory property of interleukin 10 is supposed to protect tissue from the damage caused by proinflammatory cytokines. Instea…
Manajemen pelayanan farmasi terkait dengan potensi fraud pada saat pemberian perbekalan farmasi yang dibutuhkan untuk pelayanan pasien rawat inap. Salah satunya retur perbekalan farmasi pada pasien rawat inap setelah close billing yang tinggi kemudian terjadi penurunan, hal ini berpotensi menjadi bagian dari tindakan fraud. Kejadian fraud pada permasalahan retur perbekalan farmasi di rumah …
Rumah sakit sebagai institusi pelayanan kesehatan berkomitmen pada keselamatan pasien, pengunjung, dan stafnya. Kebutuhan sarana dan prasarana untuk pelayanan dipenuhi melalui proses pengadaan barang dan jasa. Rumah sakit wajib memberikan kepuasan kepada pemasok dalam kerjasama pengadaan barang dan jasa sebagai pelanggan eksternal rumah sakit. Kepuasan pemasok merupakan hal penting bagi ruma…
Background : Thyroid storm is an endocrine disorder emergency which has a high morbidity and mortality rates. The incidence of thyroid storm is seen in less than 10% of all hospitalized thyrotoxicosis patients. However, it has a high mortality rate, which accounts to 20–30% of the cases. It is important to diagnose early to facilitate appropriate immediate management, which can improve pr…
Introduction: Hypoxia fuels cancer growth by supporting blood vessel formation, suppressing immune response, and helping cancer cells adapt to harsh surroundings. This happens when cancer cells react to low oxygen levels by activating hypoxia inducible factor-1 alpha (HIF-1α). High levels of HIF-1α can indicate an aggressive form of cancer and resistance to treatment in diffuse large B-cel…
Background Deep vein thrombosis (DVT) is a common complication in cancer. Although thromboprophylaxis in cancer patients is recommended by the guidelines, clinicians’ use of thromboprophylaxis remains limited due to cost, bleeding complications, and reluctance to give injectable anticoagulants. Infammation plays essential roles in the pathogenesis of cancer-associated thrombosis. Owing to …
Stroke is a major cause of death and disability in Indonesia. Stroke requires high-quality, fast, and precise management to prevent and avoid disability and death. Stroke can be prevented by adequately controlling the risk factors and encouraging healthy lifestyles. Efforts are needed to organize health promotion programs at the community level. More and a better distribution of neurologist…
ABSTRAKLatar Belakang:Abses abdomen merupakan kondisi yang sering ditemui pada sebagian besar kasus namun merupakan kondisi serius yang membutuhkan pengangan yang tepat dari dokter. Penegakkan diagnosis dan etiologidari abses abdomen memberikan sebuah tantangan dan peningkatanrisiko cedera pada intervensi operasi dan komplikasipostoperasi yang diperparah dengan komorbiditas, sepert…
Latar Belakang: Tiga penyebab utama kematian ibu di dunia adalah perdarahan (30%), preeklampsia (25%), dan infeksi (12%). Sebagai salah satu dari tiga besar penyebab utama morbiditas dan mortalitas ibu dan janin, insiden preeklamsia di Indonesia dilaporkan sebanyak 12.273 per tahun atau sekitar 5,3% dan belum menunjukkan adanya penurunan yang signifikan dalam dua dekade ter…
Latar Belakang:Coronavirus disease 2019 (COVID-19) adalah penyakit sistem pernapasan akut yang disebabkan oleh virus corona jenis baru (SARS-CoV-2) yang pertama kali ditemukan pada bulan Desember 2019 di Wuhan, Provinsi Hubei, China. Beberapa penyakit salah satunya diabetes mellitus, menjadi penyakit predisposisi perjalanan penyakit yang ber…
Latar Belakang: Reseksi hati untuk karsinoma hepatoseluler (HCC) saat ini dikenal sebagai prosedur yang lebih aman daripada sebelumnya karena kemajuan teknis dan perbaikan dalam manajemen pasien pascaoperasi dan tetap menjadi pengobatan lini pertama untuk HCC pada sirosis kompensasi. Hepatektomi adalah strategi pengobatan kuratif yang umum digunakan untuk pa…
Background: Spinal cystic intradural Schwannoma is a type of tumor that is rarely found, with an incidence of 0.3– 0.5/100,000 person per year. The operative procedure for this tumor was simple. However, some patients showed other comorbidities, such as heart failure with low ejection fraction (EF) and atrial fibrillation. Such cases are a challenge to the anaesthesiologist as they are mos…
Background:Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and associated with several risk factors, such as an unhealthy and unbalanced diet.Porangtubers, known as healthy diet resources, contain glucomannan, a substance that has many positive effects, such as ameliorating blood glucose.Porangtubers are processed as many food products, one of which isporang-proces…
Background:Sepsis is a condition in systemic infection associated with organ dysfunction. Interleukin-17 is a pro-inflammatory cytokine produced by Th-17 cells. C-reactive protein and neutrophil-lymphocyte ratio (NLR) have been widely used as markers of inflammation.The relationship between IL-17 as a proinflammatory cytokine with CRP and NLR has not been reported.Objective: Th…
Background: The current World Health Organization (WHO) 2021 classification of human glioma is based on key molecular biomarkers to define neoplastic entities. This review further delineates mutant IDH (isocitrate dehydrogenase) from wild-type IDH disease, a necessity given the large survival gap between mutant IDH and wild-type IDH tumors. In Indonesia, there are currently few reports on the…
Latar belakang:Epilepsi refrakter merupakan epilepsi yang tidak membaik dengan pemberian obat anti epilepsi yang adekuat. Epilepsi refrakter terjadi pada 30-40% pasien dengan epilepsi. Bedah epilepsi merupakan salah satu tatalaksana dalam epilepsi refrakter, dan penggunaan elektrokortikografi dapat membantu menentukan daerah yang dioperasi. Penggunaan obat-obatan anestesi m…
Backgrounds: Vitamin D regulates muscle function by binding to vitamin D receptors (VDR) via genomic signaling pathways. The biologically active form of vitamin D (1,25- (OH)D) affects muscles by modulation of gene transcription and protein kinase signaling pathways that support proliferation and muscle growth. Aging will result in the interaction of vitamin D and VDR, affecting the regulat…
Background:Sepsis is a systemic disorder as a result of the interaction between the immune system and infectious agents. In some cases, sepsis can progress to septic shock and death. In patients with sepsis with ongoing bacterial contamination, resuscitation may not be successful until control of the source of infection is established. Case:A 47-year-old malewith septic …